ELK-EM1328-100 μL
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Size | 100 μL |
Storage Conditions | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
Species Reactivity Cross | Human |
Applications | IHC |
Concentration | 1mg/mL |
Recomended Dilution | IHC 1:100-200 |
Type Clonality | Monoclonal |
Immunogen | Synthetic Peptide |
Subcellular Location | Cell membrane, Cytoplasm, Membrane |
Iso type | IgG1 |
Tissue Source | Mouse |
Human Gen | 197259 |
Observed Band | 54kDa |
Background | Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr |